Biomedical Research, Drug Repurposing, Clinical Trial Design and Management

OUR APPROACH

AMPEL BioSolutions employs a multipronged approach to discover new drugs.

Conceptualize Disease

A comprehensive approach aimed at understanding pathways disease causation.

Mine Data & Identify Targets

A comprehensive approach involving literature mining and bioinformatic analysis of large data sets. Using uniquely developed iterative big data analysis tools, specific disease signatures emerge that will permit crossreferencing to drug action and perturbagen data sets. The anticipated outcome is the identification of novel pathways and targets.

Design & Operationalize Clinical Trials

To solve the final piece of the drug development puzzle, AMPEL BioSolutions has managed the creation of a clinical network, developed novel clinical trial design strategies, identified unique biomarker panels and established a dialog with biotech/pharma and regulatory agencies that will permit the rapid assessment of drugs in well controlled proof-of-concept trials.

WHAT WE DO

Drug Repurposing

AMPEL BioSolutions is transformative in determining a candidate drugs’ potential as a novel disease intervention by tailoring novel therapies to apply to the right patient at the right time with the right indication. This approach involves candidate drug profiling, clinical trial design and management as well as identification of new molecular pathways for potential targeting.

Drug Repositioning

Drugs are repositioned from their FDA-approved indications into diseases with related pathogenic mechanisms. AMPEL is at the forefront of identification of drug candidates for drug repositioning.

Drug Focusing

Agents that are widely used for general health benefits are examined for their specific molecular actions applicable to unique clinical situations.

Drug Retargeting

Drugs in development with known actions that may have been intended for a specific disease can be redirected to a disease target with a greater likelihood of success during development.

Drug Rescue

Drugs that have failed in one indication may have applicability in another. Rescuing such products may generate unique and potent therapies.

Drug Redefinition

Drugs approved generally for a specific disease may require additional research to determine the specific indications that render it most beneficial.

Drug Resurrection

Useful drugs can be abandoned over time as new drugs are developed. Identifying such products and developing strategies to formulate and test them in appropriate clinical trials as well as re-acquaint clinicians of their value can lead to additional valuable therapies.

Rapid Results

Not only does AMPEL excel at an all-encompassing data analysis approach to provide the most accurate results, it quickly executes. From conception to execution, AMPEL is able to launch research ideas and mandates efficiently and effectively.

Data Analysis & Interpretation

AMPEL uses state of the art techniques to analyze clinical and research data from the literature and large databases. Expertise includes flow cytometry, gene expression (microarray and RNAseq), and bioinformatics.

Clinical Trial Design & Management

AMPEL BioSolutions is the leading biomedical research think tank that creatively overcomes clinical development bottlenecks and R&D roadblocks. AMPEL can assemble, analyze, interpret & synthesize biomedical information to provide solutions to the most pressing research needs.

New Target ID & Disease Biomarkers

Determining the most effective molecular biomarkers for evaluating pharmacodynamic activity and drug efficacy as well as the linkage between the two is an essential part of informative and successful clinical trials. Using Biologic, Molecular, Genetic and Bioinformatic approaches, AMPEL is at the forefront of identifying the newest and most accurate biomarkers.

AMPEL EXPERTISE

Autoimmunity
Immunogenicity
Immunology
Inflammation

Innate and Adaptive Immunity
Systemic Lupus Erythematosus
Lupus Nephritis

Rheumatoid Arthritis
Rheumatic Autoimmune/Inflammatory
Diseases (RAIDs)
Drug Repositioning

Clinical Design and Management
Biomarker Discovery
Bioinformatics