AC Grammer and PE Lipsky, “Drug Repositioning Strategies for the Identification of Novel Therapies for Rheumatic Autoimmune Inflammatory Diseases,” Rheum Dis Clin 43:467, 2017.
DS Pisetsky, BH Rovin and PE Lipsky, “New Perspectives in Rheumatology: Biomarkers as Entry Criteria for Clinical Trials of New Therapies for Systemic Lupus Erythematosus: The Example of Antinuclear Antibodies and Anti-DNA,” Arthritis Rheum 69:487, 2017.
LH Calabrese, A Kavanaugh, AE Yeo and PE Lipsky, “Frequency, distribution and immunologic nature of infusion reactions in subjects receiving pegloticase for chronic refractory gout,” Arthritis Res Ther 19:191, 2017.
P Lipsky, “How big data help us understand new and old therapy targets,” Ann Rheum Dis 76:38, 2017.
W Lin, P Zhang, H Chen, Y Chen, H Yang, W Zheng, X Zhang, F Zhang, W Zhang and PE Lipsky, “Circulating plasmablasts/plasma cells: a potential biomarker for IgG4-related disease,” Arthritis Res Ther 19:25, 2017.
NS Longo, T Rogosch, M Zemlin, MZouali and PE Lipsky, “Mechanisms That Shape Human Antibody Repertoire Development in Mice Transgenic for Human Ig H and L Chain Loci,” J Immunol 198:3963, 2017.
AC Grammer, MM Ryals, SE Heuer, RD Robl, S Madamanchi, LS Davis, B Lauwerys, MD Catalina and PE Lipsky, “Drug Repositioning in SLE: Crowd-Sourcing, Literature-Mining and Big Data Analysis.” Lupus 25:1150, 2016.
T. Dorner and PE Lipsky, “Beyond pan-B-cell-directed therapy — new avenues and insights into the pathogenesis of SLE,” Nature Rev Rheum 12:645, 2016
AC Grammer, MM Ryals, MD Catalina, “Repositioning Drugs for SLE” in SLE: Basic, Applied and Clinical Aspects, pp. 567, 2016.
MA Nahieu, V Strand, LS Simon, PE Lipsky and R Ramsey-Goldman, “A critical review of clinical trials in systemic lupus erythematosus,” Lupus 25:1122, 2016.
SJ Fleischer, C Daridon, V Fleischer, PE Lipsky and T Dorner, “Enhanced Tyrosine Phosphatase Activity Underlies Dysregulated B Cell Receptor Signaling and Promotes Survival of Human Lupus B Cells,” Arthritis Rheumatol 68:1210, 2016.
R Dietert and AC Grammer, “The Epigenetics of Autoimmunity & Immune Disorders” in The Epigenome and Developmental Origins of Adult Health and Disease, 2015. 211, 2015.
Dorner, A Shock, DM Goldenberg and and PE Lipsky, “The mechanistic impact of CD22 engagement with epratuzumab on B cell function: Implications for the treatment of systemic lupus erythematosus,” Autoimmun Rev 14:1079, 2015.
W Lin, S Lu, H Chen, Q Wu, Y Fei, M Li, X Zhang, X Tian, W Zheng, X Leng, D Xu, Q Wang, M Shen, L Wang, J Li, D Wu, L Zhao, C Wu, Y Yang, L Peng, J Zhou, Y Wang, Y Sha, X Huang, Y Jiao, X Zeng, Q Shi, P Li, S Zhang, C Hu, C Deng, Y Li,S Zhang, J Liu, J Su, Y Hou, Y Jiang, X You, H Zhang, L Yan, W Zhang, Y Zhao,X Zeng, F Zhang and PE Lipsky, “Clinical characteristics of immunoglobulin G4-relateddisease: a prospective study of 118 Chinese patients,” Rheumatology 54:1982, 2015.
AC Grammer, M Ryals and PE Lipsky, “A comprehensive approach to identify approved drugs and treatments for repositioning as therapies for systemic lupus erythematosus.” Arthr. Res. Ther. 16: 51, 2014.
Dorner and PE Lipsky, “B cells: depletion of functional modulation in rheumatic diseases,” Curr Opin Rheumatol. 26: 228, 2014.
JH Sim, HR Kim, SH Chang, IJ Kim, PE Lipsky and J Lee, “Autoregulatory function of interleukin-10-producing pre-naïve B cells is defective in systemic lupus erythematosus,” Arthritis Res Ther 17:190, 2015.
SJ Fleischer, C Giesecke, HE Mei, PE Lipsky, C Daridon and T. Dorner, “Increased frequency of a unique spleen tyrosine kinase bright memory B cell population in systemic lupus erythematosus,” Arthritis Rheumatol 66:3424, 2014.
XN Wu, YX Ye, JW Niu, Y Li, X Li, X You, H Chen, LD Zhao, XF Zeng, FC Zhang, FL Tang, W He, XT Cao, X Zhang and PE Lipsky, “Defective PTEN regulation contributes to B cell hyperresponsiveness in systemic lupus erythematosus,” Sci Transl Med.6:246ra99, 2014.
QW Lv, W Zhang, Q Shi, WJ Zheng, X Li, H Chen, QJ Wu, WL Jiang, HB Li, L Gong, W Wei, H Liu, AJ Liu, HT Jin, JX Wang, XM Liu, ZB Li, B Liu, M Shen, Q Wang, XN Wu, D Liang, YF Yin, YY Fei, JM Su, LD Zhao, Y Jiang, J Li, FL Tang, FC Zhang, PE Lipsky and X Zhang, “Comparison of Tripterygium wilfordii Hook F (Thunder God Vine) with methotrexate in the treatment of active rheumatoid arthritis (TRIFRA): a randomised, controlled clinical trial,” Ann Rheum Dis. 74:1078, 2015.
PE Lipsky, LH Calabrese, A Kavanaugh, JS Sundy, D Wright, M Wolfson and MA Becker, “Pegloticase immunogenicity: the relationship between efficacy and antibody development in patients treated for refractory chronic gout,” Arthritis Res Ther. 16:R60, 2014.
C Giesecke, D Frölich, K Reiter, HE Mei, I Wirries, R Kuhly, M Killig, T Glatzer, K Stölzel, C Perka, PE Lipsky and T Dorner, “Tissue distribution and dependence of responsiveness of human antigen-specific memory B cells,” J Immunol. 192:3091, 2014.
B cells: depletion or functional modulation in rheumatic diseases.
Dörner T, et al. Curr Opin Rheumatol. 2014
Y Shirota, C Yarboro, R Fischer, TH Pham, P Lipsky and GG Illei, “Impact of anti-interleukin-6 receptor blockade on circulating T and B cell subsets in patients with systemic lupus erythematosus,” Ann Rheum Dis 72:118, 2013.
Molecular characterization of circulating plasma cells in patients with active systemic lupus erythematosus.
Lugar PL, et al. PLoS One. 2012