AC Grammer and PE Lipsky, “Drug Repositioning Strategies for the Identification of Novel Therapies for Rheumatic Autoimmune Inflammatory Diseases,” Rheum Dis Clin 43:467, 2017.

DS Pisetsky, BH Rovin and PE Lipsky, “New Perspectives in Rheumatology: Biomarkers as Entry Criteria for Clinical Trials of New Therapies for Systemic Lupus Erythematosus: The Example of Antinuclear Antibodies and Anti-DNA,” Arthritis Rheum 69:487, 2017.

LH Calabrese, A Kavanaugh, AE Yeo and PE Lipsky, “Frequency, distribution and immunologic nature of infusion reactions in subjects receiving pegloticase for chronic refractory gout,” Arthritis Res Ther 19:191, 2017.

P Lipsky, “How big data help us understand new and old therapy targets,” Ann Rheum Dis 76:38, 2017.

W Lin, P Zhang, H Chen, Y Chen, H Yang, W Zheng, X Zhang, F Zhang, W Zhang and PE Lipsky, “Circulating plasmablasts/plasma cells: a potential biomarker for IgG4-related disease,” Arthritis Res Ther 19:25, 2017.

NS Longo, T Rogosch, M Zemlin, MZouali and PE Lipsky, “Mechanisms That Shape Human Antibody Repertoire Development in Mice Transgenic for Human Ig H and L Chain Loci,” J Immunol 198:3963, 2017.

AC Grammer, MM Ryals, SE Heuer, RD Robl, S Madamanchi, LS Davis, B Lauwerys, MD Catalina and PE Lipsky, “Drug Repositioning in SLE: Crowd-Sourcing, Literature-Mining and Big Data Analysis.” Lupus 25:1150, 2016.

T. Dorner and PE Lipsky, “Beyond pan-B-cell-directed therapy — new avenues and insights into the pathogenesis of SLE,” Nature Rev Rheum 12:645, 2016

AC Grammer, MM Ryals, MD Catalina, “Repositioning Drugs for SLE” in SLE: Basic, Applied and Clinical Aspects, pp. 567, 2016.

MA Nahieu, V Strand, LS Simon, PE Lipsky and R Ramsey-Goldman, “A critical review of clinical trials in systemic lupus erythematosus,” Lupus 25:1122, 2016.

SJ Fleischer, C Daridon, V Fleischer, PE Lipsky and T Dorner, “Enhanced Tyrosine Phosphatase Activity Underlies Dysregulated B Cell Receptor Signaling and Promotes Survival of Human Lupus B Cells,” Arthritis Rheumatol 68:1210, 2016.

R Dietert and AC Grammer, “The Epigenetics of Autoimmunity & Immune Disorders” in The Epigenome and Developmental Origins of Adult Health and Disease, 2015. 211, 2015.

Dorner, A Shock, DM Goldenberg and and PE Lipsky, “The mechanistic impact of CD22 engagement with epratuzumab on B cell function: Implications for the treatment of systemic lupus erythematosus,” Autoimmun Rev 14:1079, 2015.

W Lin, S Lu, H Chen, Q Wu, Y Fei, M Li,  X Zhang, X Tian, W Zheng, X Leng, D Xu, Q Wang, M Shen, L Wang, J Li, D Wu, L Zhao, C Wu, Y Yang, L Peng, J Zhou, Y Wang, Y Sha, X Huang, Y Jiao, X Zeng, Q Shi, P Li, S Zhang, C Hu, C Deng, Y Li,S Zhang, J Liu, J Su, Y Hou, Y Jiang, X You, H Zhang, L Yan, W Zhang, Y Zhao,X Zeng, F Zhang and PE Lipsky, “Clinical characteristics of immunoglobulin G4-relateddisease: a prospective study of 118 Chinese patients,” Rheumatology 54:1982, 2015.

AC Grammer, M Ryals and PE Lipsky, “A comprehensive approach to identify approved drugs and treatments for repositioning as therapies for systemic lupus erythematosus.”  Arthr. Res. Ther. 16: 51, 2014.

Dorner and PE Lipsky, “B cells: depletion of functional modulation in rheumatic diseases,” Curr Opin Rheumatol. 26: 228, 2014.

JH Sim, HR Kim, SH Chang, IJ Kim, PE Lipsky and J Lee, “Autoregulatory function of interleukin-10-producing pre-naïve B cells is defective in systemic lupus erythematosus,” Arthritis Res Ther 17:190, 2015.

SJ Fleischer, C Giesecke, HE Mei, PE Lipsky, C Daridon and T. Dorner, “Increased frequency of a unique spleen tyrosine kinase bright memory B cell population in systemic lupus erythematosus,” Arthritis Rheumatol 66:3424, 2014.

XN Wu, YX Ye, JW Niu, Y Li, X Li, X You, H Chen, LD Zhao, XF Zeng, FC Zhang, FL Tang, W He, XT Cao, X Zhang and PE Lipsky, “Defective PTEN regulation contributes to B cell hyperresponsiveness in systemic lupus erythematosus,” Sci Transl Med.6:246ra99, 2014.

QW Lv, W Zhang, Q Shi, WJ Zheng, X Li, H Chen, QJ Wu, WL Jiang, HB Li, L Gong, W Wei, H Liu, AJ Liu, HT Jin, JX Wang, XM Liu, ZB Li, B Liu, M Shen, Q Wang, XN Wu, D Liang, YF Yin, YY Fei, JM Su, LD Zhao, Y Jiang, J Li, FL Tang, FC Zhang, PE Lipsky and X Zhang, “Comparison of Tripterygium wilfordii Hook F (Thunder God Vine) with methotrexate in the treatment of active rheumatoid arthritis (TRIFRA): a randomised, controlled clinical trial,” Ann Rheum Dis. 74:1078, 2015.

PE Lipsky, LH Calabrese, A Kavanaugh, JS Sundy, D Wright, M Wolfson and MA Becker, “Pegloticase immunogenicity: the relationship between efficacy and antibody development in patients treated for refractory chronic gout,” Arthritis Res Ther. 16:R60, 2014.

C Giesecke, D Frölich, K Reiter, HE Mei, I Wirries, R Kuhly, M Killig, T Glatzer, K Stölzel, C Perka, PE Lipsky and T Dorner, “Tissue distribution and dependence of responsiveness of human antigen-specific memory B cells,” J Immunol. 192:3091, 2014.

B cells: depletion or functional modulation in rheumatic diseases.
Dörner T, et al. Curr Opin Rheumatol. 2014

Y Shirota, C Yarboro, R Fischer, TH Pham, P Lipsky and GG Illei, “Impact of anti-interleukin-6 receptor blockade on circulating T and B cell subsets in patients with systemic lupus erythematosus,” Ann Rheum Dis 72:118, 2013.

Molecular characterization of circulating plasma cells in patients with active systemic lupus erythematosus.
Lugar PL, et al. PLoS One. 2012

Splenic proliferative lymphoid nodules distinct from germinal centers are sites of autoantigen stimulation in immune thrombocytopenia.
Daridon C, et al. Blood. 2012

Aberrant CD200/CD200R1 expression and function in systemic lupus erythematosus contributes to abnormal T-cell responsiveness and dendritic cell activity.
Li Y, et al. Arthritis Res Ther. 2012